Khutorsky V E
Chemistry Department, Ben Gurion University of the Negev, Beer-Sheva, Israel.
Biophys Chem. 1997 Dec 1;69(2-3):161-6. doi: 10.1016/s0301-4622(97)00086-0.
The ionophore lasalocid A selectively transports amines across lipid membranes. Free energy differences of amine-lasalocid complex formation reactions and the activation barriers of the complex transport were calculated by the finite difference thermodynamic integration method. Four catecholamines were treated: serotonin > dopamine > noradrenaline > adrenaline. The concept of transfer selectivity was introduced, combining binding and activation barrier selectivities. The transfer selectivities correlate well with the relative selectivities of the amines under study.
