Kinsel J F, Melnik E I, Sternson L A, Lindenbaum S
Biochim Biophys Acta. 1982 Nov 22;692(3):377-83. doi: 10.1016/0005-2736(82)90387-x.
The ionophore antibiotic X-537A (lasalocid) transports biogenic amines across biological and artificial membranes. The major portion of amine flux (greater than 99%) occurs as a 1:1 neutral complex. The rank order of ionophore selectivity was determined for lipid bilayer membrane transport of amines based on a comparison of permeability coefficients: p-tyramine approximately beta-phenylethylamine approximately amphetamine greater than methamphetamine greater than dopamine greater than phenylephrine approximately metanephrine greater than norepinephrine greater than epinephrine. This rank order is in agreement with results obtained from partitioning measurements which were carried out in parallel to the bilayer membrane experiments. A correlation between amine structure and binding characteristics has been developed.
离子载体抗生素X-537A（拉沙洛西）可使生物胺穿过生物膜和人工膜。胺通量的主要部分（超过99%）以1:1的中性复合物形式出现。基于渗透系数的比较，确定了离子载体对脂质双层膜转运胺的选择性顺序：对酪胺≈β-苯乙胺≈苯丙胺＞甲基苯丙胺＞多巴胺＞去氧肾上腺素≈变肾上腺素＞去甲肾上腺素＞肾上腺素。该选择性顺序与平行于双层膜实验进行的分配测量结果一致。已建立了胺结构与结合特性之间的相关性。
