Kancherla Vikas S, Hanson I Celine
Allergy/Immunology Section, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, USA.
J Allergy Clin Immunol. 2006 Oct;118(4):938-41. doi: 10.1016/j.jaci.2006.07.033. Epub 2006 Aug 28.
The recent mumps epidemic in the central United States has generated a large amount of public concern. A total of 2597 mumps cases have been reported in the United States in 11 states since January 1, 2006, representing a marked resurgence of mumps in a single year. The majority of these recent cases have occurred in college students age 18 to 25 years. Most were vaccinated with 2 doses of measles, mumps, and rubella-containing vaccines. Such outbreaks provide an opportunity for clinicians to review the clinical presentation, diagnosis, and morbidity of vaccine-preventable infections and also to review immunologic mechanisms and practice guidelines that might contribute to poor vaccine responses. A review of mumps is provided with discussion of potential mechanisms for vaccine failure.
美国中部近期爆发的腮腺炎疫情引发了公众的广泛关注。自2006年1月1日以来，美国11个州共报告了2597例腮腺炎病例，这表明腮腺炎在短短一年内显著复发。这些近期病例中的大多数发生在18至25岁的大学生中。大多数人都接种了两剂含麻疹、腮腺炎和风疹的疫苗。此类疫情爆发为临床医生提供了一个机会，来回顾疫苗可预防感染的临床表现、诊断和发病率，同时也回顾可能导致疫苗反应不佳的免疫机制和实践指南。本文对腮腺炎进行了综述，并讨论了疫苗失效的潜在机制。
