B细胞非霍奇金淋巴瘤中T细胞的表型异常
Phenotypic abnormality of T cells in B cell non-Hodgkin's lymphoma.
作者信息
Sewell H F, MacKenzie R H, Dawson A A, Ratcliffe M A, King D J, Bennett N B
机构信息
Department of Pathology, Aberdeen Royal Infirmary, Foresterhill.
出版信息
Dis Markers. 1990 May-Jun;8(3):145-9.
PMID:1703060
Abstract
CD4+ T cells of patients with B cell non-Hodgkin's lymphoma (NHL) were analysed for expression of CD45RA and CD29. It was found that CD45RA expression was significantly lower, and CD29 expression significantly higher, in lymphoma patients compared to normal controls. Moreover absolute numbers of CD4+ T cells were significantly lower in NHL patients, due to selective depletion of CD4+ CD45RA+ cells.
摘要
对B细胞非霍奇金淋巴瘤（NHL）患者的CD4 + T细胞进行了CD45RA和CD29表达分析。结果发现，与正常对照相比，淋巴瘤患者的CD45RA表达显著降低，而CD29表达显著升高。此外，由于CD4 + CD45RA +细胞的选择性耗竭，NHL患者CD4 + T细胞的绝对数量显著降低。
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