具有单个载脂蛋白Eε4等位基因的认知功能正常成年人的局部脑萎缩。
Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele.
作者信息
Wishart H A, Saykin A J, McAllister T W, Rabin L A, McDonald B C, Flashman L A, Roth R M, Mamourian A C, Tsongalis G J, Rhodes C H
机构信息
Department of Psychiatry, Dartmouth Medical School/DHMC, Lebanon, NH 03756-0001, USA.
出版信息
Neurology. 2006 Oct 10;67(7):1221-4. doi: 10.1212/01.wnl.0000238079.00472.3a.
OBJECTIVE
To determine whether cognitively intact adults with the APOE epsilon3/epsilon4 genotype show reduced gray matter density on voxel-based morphometry (VBM) vs those homozygous for the epsilon3 allele.
METHODS
Participants were healthy, cognitively intact, right-handed adults, age 19 to 80, who completed genotyping, neuropsychological testing, and MRI. Forty-nine participants had the epsilon3/epsilon3 genotype and 27 had the epsilon3/epsilon4 genotype. Gray matter data were analyzed using the general linear model as implemented in the Statistical Parametric Mapping package, adjusting for age and sex.
RESULTS
The epsilon3/epsilon4 participants showed lower gray matter density than the epsilon3/epsilon3 participants in right medial temporal and bilateral frontotemporal regions as well as other areas. There were no regions in which epsilon3/epsilon4 participants showed higher gray matter density than epsilon3/epsilon3 participants.
CONCLUSIONS
Regionally reduced gray matter density is detectable in cognitively intact adults with a single copy of the APOE epsilon4 allele.
目的
确定携带APOE ε3/ε4基因型的认知功能正常的成年人与ε3等位基因纯合子相比，基于体素的形态测量法（VBM）显示其灰质密度是否降低。
方法
参与者为年龄在19至80岁之间、健康、认知功能正常的右利手成年人，他们完成了基因分型、神经心理学测试和磁共振成像（MRI）。49名参与者具有ε3/ε3基因型，27名具有ε3/ε4基因型。使用统计参数映射软件包中实现的一般线性模型对灰质数据进行分析，并对年龄和性别进行校正。
结果
携带ε3/ε4基因型的参与者在右侧颞叶内侧、双侧额颞叶区域以及其他区域的灰质密度低于携带ε3/ε3基因型的参与者。没有区域显示携带ε3/ε4基因型的参与者的灰质密度高于携带ε3/ε3基因型的参与者。
结论
在携带单个APOE ε4等位基因拷贝的认知功能正常的成年人中，可检测到局部灰质密度降低。
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