Wulfhekel U, Düllmann J
Anatomisches Institut, Universität Bonn, FRG.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1990;117(3):419-34.
The light and electronmicroscopic representation of non-haemiron in the bone-marrow provides the unique opportunity of extensively evaluating the iron metabolism. In the bone-marrow, macrophages represent the physiological place of iron storage. The iron in the cytoplasma is stored in them in the form of free ferritin molecules and lysomally as aggregated ferritin and/or haemosiderin in siderosomes. In an equal iron balance and unimpaired internal iron exchange only erythroblasts (sideroblasts) and erythrocytes (siderocytes) of the bone-marrow besides macrophages possess siderosomes. In addition to this physiological or orthotopic iron storage a heterotopic iron storage can be observed under pathological conditions, particularly with iron overloading of the organism, in the endothelial cells of sinusoids and plasma cells. In detail, the patterns of iron storage in the bone-marrow are described in the different stages of iron deficiency, disturbance of iron utilization in chronically inflammatory processes or tumour diseases, condition after intravenous iron administration, transfusion siderosis, hereditary haemochromatosis and sideroblastic anaemia.
骨髓中非血红素铁的光镜和电镜表现为广泛评估铁代谢提供了独特的机会。在骨髓中，巨噬细胞是铁储存的生理场所。细胞质中的铁以游离铁蛋白分子的形式储存于其中，并以聚集的铁蛋白和/或铁血黄素的形式存在于溶酶体中的含铁小体中。在铁平衡正常且内部铁交换未受损害的情况下，除巨噬细胞外，骨髓中只有成红细胞（环形铁粒幼细胞）和红细胞（含铁血红细胞）含有含铁小体。除了这种生理性或原位铁储存外，在病理条件下，尤其是机体铁过载时，可在血窦内皮细胞和浆细胞中观察到异位铁储存。详细地说，在缺铁的不同阶段、慢性炎症过程或肿瘤疾病中铁利用障碍、静脉注射铁剂后的情况、输血性含铁血黄素沉着症、遗传性血色素沉着症和铁粒幼细胞性贫血中，描述了骨髓中铁储存的模式。
