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因出血而掩盖的原发性铁粒幼细胞贫血。

Primary sideroblastic anemia masked by bleeding.

作者信息

Popescu E R, Fitzgerald M E, Martelo O J

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1978;105(2):255-9.

PMID:79531
Abstract

A patient with characteristic features of iron deficiency was unexpectedly found to have circulating siderocytes. Bone marrow iron stain at this time showed absence of both hemosiderin and ringed sideroblasts; electron microscopy revealed absence of mitochondrial iron loading but presence of cytoplasmic ferritin in normoblasts. Replenishment of iron stores led to development of typical sideroblastic anemia. These observations suggest that increased percentage of siderocytes in otherwise typical iron deficiency anemia may signify the presence of a sideroblastic process masked by iron deficiency due to bleeding.

摘要

一名具有缺铁特征的患者意外发现有循环中的含铁红细胞。此时骨髓铁染色显示含铁血黄素和环形铁粒幼细胞均缺失;电子显微镜检查显示线粒体铁负荷缺失,但正成红细胞中有细胞质铁蛋白存在。补充铁储备后导致典型的铁粒幼细胞性贫血的发生。这些观察结果表明,在其他方面典型的缺铁性贫血中,含铁红细胞百分比增加可能意味着存在因出血导致的缺铁所掩盖的铁粒幼细胞生成过程。

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