Levine P H, Diamond R D, Reisher J I
J Clin Microbiol. 1975 Apr;1(4):363-5. doi: 10.1128/jcm.1.4.363-365.1975.
Antibody levels to the Epstein-Barr virus, the etiological agent for heterophile-positive infectious mononucleosis, have been demonstrated in high titer in a number of lymphomas as well as infectious mononucleosis. Recent reports have suggested that the elevated antibody levels to Epstein-Barr virus may be the nonspecific result of disordered cell-mediated immunity. This study of patients with cryptococcosis was therefore undertaken to examine another disorder of known etiology associated with a defect in cell-mediated immunity. In this study we found that antibody levels in cryptococcosis patients, including a group specifically demonstrated to be anergic to a series of skin test antigens, were no different than those in matched normal controls. At the present time, therefore, it is unlikely that elevated antibody levels can be explained solely on the basis of depressed cellular immunity.
嗜异性抗体阳性传染性单核细胞增多症的病原体是爱泼斯坦-巴尔病毒，在一些淋巴瘤以及传染性单核细胞增多症患者中已证实其抗体水平呈高滴度。最近的报告表明，爱泼斯坦-巴尔病毒抗体水平升高可能是细胞介导免疫紊乱的非特异性结果。因此，对隐球菌病患者进行了这项研究，以检查另一种已知病因且与细胞介导免疫缺陷相关的疾病。在本研究中，我们发现隐球菌病患者的抗体水平，包括一组经专门证实对一系列皮肤试验抗原有无反应性的患者，与配对的正常对照组并无差异。因此，目前抗体水平升高不太可能仅基于细胞免疫抑制来解释。
