Seigneurin J M, Kressmann M C, Lavoué M F, Saez G, Lenoir G
Nouv Presse Med. 1978 Dec 9;7(44):4005-10.
Thirty-seven patients--aged 2 to 58--with clinical and hematological signs of infectious mononucleosis were studied. Thirty patients gave serologic evidence of Epstein-Barr virus infections; antibodies to viral capsid antigen (VCA) appeared very early (only two seroconversions and 4 cases of increased titer were detected); antibodies to early antigen (EA) occured in 25 patients, but only 9 had high titers; antibodies to nuclear antigen (EBNA) appeared late in the course of the disease. VCA-specific IgM antibodies occurred in 25 cases (they usually disappeared during the 2nd month). The transforming EB virus was found in the saliva of the 2 patients where we looked for it. Heterophile antibody responses occured in only 17 patients; among children about half of them had a positive Paul-Bunnell-Davidsohn test. After the age of 40 (3 cases) heterophile antibodies were no longer found. Three patients had another recent viral infection at the same time as the primary EBV infection (two cases of rubella, one case of adenovirus infection). Of the remaining 7 patients (having either no antibodies to EBV or antibodies of past infection), 2 had cytomegalovirus infections and one rubella.
对37例年龄在2至58岁之间、有传染性单核细胞增多症临床和血液学体征的患者进行了研究。30例患者有EB病毒感染的血清学证据；病毒衣壳抗原（VCA）抗体出现得非常早（仅检测到2例血清转化和4例滴度升高）；25例患者出现早期抗原（EA）抗体，但只有9例滴度高；核抗原（EBNA）抗体在疾病后期出现。25例患者出现VCA特异性IgM抗体（它们通常在第2个月消失）。在我们检测的2例患者的唾液中发现了具有转化能力的EB病毒。仅17例患者出现嗜异性抗体反应；在儿童中，约一半患者的嗜异性凝集试验呈阳性。40岁以后（3例）未再发现嗜异性抗体。3例患者在原发性EB病毒感染的同时还患有另一种近期病毒感染（2例风疹，1例腺病毒感染）。其余7例患者（要么没有EB病毒抗体，要么有既往感染的抗体）中，2例患有巨细胞病毒感染，1例患有风疹。
