麻风病患者对爱泼斯坦-巴尔病毒和巨细胞病毒感染的宿主反应。
Host responses to Epstein-Barr virus and cytomegalovirus infection in leprosy.
作者信息
Papageorgiou P S, Sorokin C F, Kouzoutzakoglou K, Bonforte R J, Workman P L, Glade P R
出版信息
Infect Immun. 1973 Apr;7(4):620-4. doi: 10.1128/iai.7.4.620-624.1973.
A study was undertaken in patients with leprosy to assess the contribution of cell-mediated immunity to the host response to Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection. Sixteen of 72 patients (22%) with lepromatous leprosy, with impaired cellular immunity, had anti-EBV titers of 1,640 or higher. Only 4 of 49 patients (8%) with tuberculoid leprosy, with intact cell-mediated immunity, attained the level of 1:640. The anti-EBV antibody titers were significantly higher in patients with lepromatous leprosy (P approximately 0.025). No significant differences were found in the level of anti-CMV antibody titers in patients with the two types of leprosy. The presence of high anti-EBV antibody titers in lepromatous leprosy suggests that cell-mediated immunity is a significant factor in host response to EBV infection. Host immune responses should be taken into consideration when assignment of an etiological role to EBV is based upon seroepidemiological data.
开展了一项针对麻风病患者的研究，以评估细胞介导免疫在宿主对爱泼斯坦-巴尔病毒（EBV）和巨细胞病毒（CMV）感染反应中的作用。72例瘤型麻风患者中，16例（22%）细胞免疫受损，其抗EBV滴度为1640或更高。49例结核样型麻风患者中，仅4例（8%）细胞介导免疫正常，其抗EBV滴度达到1:640水平。瘤型麻风患者的抗EBV抗体滴度显著更高（P约为0.025）。两种类型麻风患者的抗CMV抗体滴度水平未发现显著差异。瘤型麻风患者中存在高抗EBV抗体滴度表明，细胞介导免疫是宿主对EBV感染反应的一个重要因素。当基于血清流行病学数据将病因作用归因于EBV时，应考虑宿主免疫反应。
Zotero 插件