Baffoe-Bonnie Agnes B, Kittles Rick A, Gillanders Elizabeth, Ou Liang, George Asha, Robbins Christiane, Ahaghotu Chiledum, Bennett James, Boykin William, Hoke Gerald, Mason Terry, Pettaway Curtis, Vijayakumar Srinivasan, Weinrich Sally, Jones Mary P, Gildea Derek, Riedesel Erica, Albertus Julie, Moses Tracy, Lockwood Erica, Klaric Meghan, Faruque Mezbah, Royal Charmaine, Trent Jeffrey M, Berg Kate, Collins Francis S, Furbert-Harris Paulette M, Bailey-Wilson Joan E, Dunston Georgia M, Powell Isaac, Carpten John D
Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Prostate. 2007 Jan 1;67(1):22-31. doi: 10.1002/pros.20456.
The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of >or=4 affected.
We present a approximately 10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped.
Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores >or=1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families >or=2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (alpha = 0.33) at the Xq21 locus. Two novel peaks >or=0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12.
These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families.
非裔美国人遗传性前列腺癌（AAHPC）研究旨在招募早发性疾病且符合≥4名患者标准的家族。
我们对77个家族进行了约10厘摩的全基因组连锁（GWL）分析，其中包括254名患病者和274名未患病者的基因分型。
连锁分析显示，在11q22、17p11和Xq21区域，GENEHUNTER多点HLOD得分≥1.3的三个染色体区域，涉及所有77个家族。一个家族在17p11区域产生了全基因组显著的连锁证据（LOD = 3.5），该区域还有其他七个家族的LOD≥2.3。29个无男性对男性（MM）传递的家族在Xq21位点的最高HLOD为1.62（α = 0.33）。对于16个“≥6名患者”的家族，在2p21和22q12区域出现了两个新的峰值≥0.91。
基于多个效应适度的易感基因或在家族小子集中分离的几个主要基因的假设，基因组中的这些染色体区域值得进一步随访。
