Sequence comparison between the fusion protein of human and bovine respiratory syncytial viruses.

作者信息

Walravens K, Kettmann R, Collard A, Coppe P, Burny A

机构信息

Laboratoire de Microbiologie et d'Immunologie, Faculté Universitaire Notre Dame de la Paix, Namur, Belgium.

出版信息

J Gen Virol. 1990 Dec;71 ( Pt 12):3009-14. doi: 10.1099/0022-1317-71-12-3009.

The nucleotide sequence was determined for the fusion (F) protein-coding mRNA of the bovine respiratory syncytial virus (strain RB 94) and the amino acid sequence of the F protein was deduced for comparison with the sequence of human respiratory syncytial virus subtypes A and B (RSS-2 and 18537 strains). The human and bovine RS virus F proteins (excluding the cleaved signal peptide) share 83 to 84% homology. The greatest divergence occurred within the F2 subunit in the region preceding the cleavage activation site.