三名线粒体疾病患儿脑干存在持续性扩散异常。
Persistent diffusion abnormalities in the brain stem of three children with mitochondrial diseases.
作者信息
Sakai Y, Kira R, Torisu H, Ihara K, Yoshiura T, Hara T
机构信息
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
出版信息
AJNR Am J Neuroradiol. 2006 Oct;27(9):1924-6.
Abstract
We report 2 children (patients 1 and 2) with Kearns-Sayre syndrome and 1 (patient 3) with Leigh syndrome, who underwent serial diffusion-weighted MR imaging (DWI) studies for 2.8 (patient 1), 4.2 (patient 2), and 1.0 years (patient 3). The DWI revealed the persistent hyperintense signals in the pontine and mesencephalic tegmenta. The apparent diffusion coefficient in the affected regions remained constantly low, suggesting that cytotoxic edema and spongiform degenerations may compose these brain stem lesions.
摘要
我们报告了2例患有卡恩斯-塞尔综合征的儿童（患者1和患者2）以及1例患有 Leigh 综合征的儿童（患者3），他们分别接受了2.8年（患者1）、4.2年（患者2）和1.0年（患者3）的连续扩散加权磁共振成像（DWI）研究。DWI显示脑桥和中脑被盖持续存在高信号。受累区域的表观扩散系数持续偏低，提示细胞毒性水肿和海绵状变性可能构成这些脑干病变。
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