[1例晚期直肠癌对基于口服优福定和亚叶酸的术前放化疗有反应]
[A case of advanced rectal cancer responding to oral UFT and Leucovorin-based preoperative chemoradiation therapy].
作者信息
Shibahara Kotaro, Hirazuka Takahiro, Yamamoto Manabu, Ninomiya Mizuki, Mashino Kojiro, Fuji Kyuzo, Ikeda Tetsuo, Kahno Tadashi
机构信息
Dept. of Surgery, Oita Prefectural Hospital.
出版信息
Gan To Kagaku Ryoho. 2006 Oct;33(10):1481-3.
We report a case of a 44-year-old male with advanced lower rectal cancer that showed a significant effect after preoperative chemoradiation therapy. Preoperative radiation and chemotherapy included whole pelvis irradiation (30 Gy in total), oral UFT (500 mg/day), and Leucovorin (75 mg/day) was administered daily for 4 weeks. Consequently, the patient underwent a total pelvic exenteration with lymph node dissection (D 3). Histopathological findings showed: invasion to peritoneum(Ai); stage IIIa with n(-); and histological grading, Grade 2. Preoperative chemoradiation therapy appears to be effective for locally advanced lower rectal cancer.
我们报告一例44岁男性晚期低位直肠癌患者，其在术前放化疗后显示出显著疗效。术前放疗和化疗包括全盆腔照射（总量30 Gy），口服优福定（500 mg/天），并每天给予亚叶酸钙（75 mg/天），持续4周。因此，该患者接受了全盆腔脏器切除术及淋巴结清扫术（D3）。组织病理学检查结果显示：侵犯至腹膜（Ai）；Ⅲa期，n（-）；组织学分级为2级。术前放化疗似乎对局部晚期低位直肠癌有效。
Zotero 插件