Seoane L M, Al-Massadi O, Pazos Y, Pagotto U, Casanueva F F
Endocrinología Molecular, Area de Investigación, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain.
J Endocrinol Invest. 2006 Sep;29(8):RC13-5. doi: 10.1007/BF03344174.
The isolation of ghrelin unveiled a new system implicated in food intake regulation. The recently isolated hormone obestatin derives from the same precursor of ghrelin and seems to perform opposite actions. It could be part of a dual system connecting gut and brain to regulate energy homeostasis. The ability of intracerebroventricular administration of obestatin to modify food intake was evaluated. Obestatin had no effect on spontaneous food intake in both ad libitum and food restricted rats. The obestatin injection was not able to antagonize the ghrelin-stimulated increase in food intake either. In conclusion, the present work does not support a role for obestatin on the regulation of food intake in any model studied.
胃饥饿素的分离揭示了一个与食物摄入调节有关的新系统。最近分离出的激素肥胖抑制素源自胃饥饿素的同一前体，且似乎发挥着相反的作用。它可能是连接肠道和大脑以调节能量平衡的双重系统的一部分。评估了脑室内注射肥胖抑制素对食物摄入的影响。肥胖抑制素对自由进食和限食大鼠的自发食物摄入均无影响。注射肥胖抑制素也无法拮抗胃饥饿素刺激引起的食物摄入量增加。总之，目前的研究不支持肥胖抑制素在任何所研究模型的食物摄入调节中发挥作用。
