Wren A M, Small C J, Ward H L, Murphy K G, Dakin C L, Taheri S, Kennedy A R, Roberts G H, Morgan D G, Ghatei M A, Bloom S R
Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
Endocrinology. 2000 Nov;141(11):4325-8. doi: 10.1210/endo.141.11.7873.
Ghrelin, a novel 28 amino acid peptide found in hypothalamus and stomach, was recently identified as the endogenous ligand for the growth hormone secretagogue receptor (GHS-R). We have now found that both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) administration of ghrelin in freely feeding rats stimulated food intake. The onset of increased feeding was rapid and after i.c.v. administration was sustained for 24 hours. Following i.c.v. administration of 3 nmol ghrelin, the duration and magnitude of the feeding stimulation was similar to that following 5 nmol neuropeptide Y (NPY). Plasma growth hormone (GH) concentration increased following both i.c.v. and i.p. administration of ghrelin. Release of adrenocorticotrophic hormone (ACTH) was stimulated and thyroid stimulating hormone (TSH) inhibited following i.c.v. administration of ghrelin. These data suggest a possible role for the newly identified endogenous hypothalamic peptide, ghrelin, in stimulation of feeding and growth hormone secretion.
胃饥饿素是一种在下丘脑和胃中发现的由28个氨基酸组成的新型肽，最近被确定为生长激素促分泌素受体（GHS-R）的内源性配体。我们现已发现，对自由进食的大鼠进行脑室注射（i.c.v.）和腹腔注射（i.p.）胃饥饿素均可刺激食物摄入。进食增加的起始迅速，脑室注射后可维持24小时。脑室注射3 nmol胃饥饿素后，进食刺激的持续时间和程度与注射5 nmol神经肽Y（NPY）后的情况相似。脑室注射和腹腔注射胃饥饿素后，血浆生长激素（GH）浓度均升高。脑室注射胃饥饿素后，促肾上腺皮质激素（ACTH）的释放受到刺激，促甲状腺激素（TSH）受到抑制。这些数据表明，新发现的内源性下丘脑肽胃饥饿素在刺激进食和生长激素分泌方面可能发挥作用。
