Ison C A
Department of Medical Microbiology, Imperial College School of Medicine, St Mary's Hospital, London, UK.
Curr Opin Infect Dis. 1998 Feb;11(1):43-6. doi: 10.1097/00001432-199802000-00010.
Genotyping of Neisseria gonorrhoeae has proved highly discriminatory. It has been used to differentiate between isolates of the same serovar, to determine the genetic relatedness of antibiotic resistant isolates and to identify isolates from sexual contacts. This level of resolution has been possible because Neisseria gonorrhoeae exhibits a high degree of genetic variability. The validity of using any typing technique to study temporal or geographical differences of an organism known to be non-clonal should, however, be carefully considered.
淋病奈瑟菌的基因分型已被证明具有高度的鉴别力。它已被用于区分同一血清型的分离株，确定耐药分离株的遗传相关性，并识别性接触者的分离株。之所以能够达到这种分辨率水平，是因为淋病奈瑟菌表现出高度的遗传变异性。然而，对于使用任何分型技术来研究已知为非克隆性生物体的时间或地理差异的有效性，都应谨慎考虑。
