甲磺酸伊马替尼诱导的具有自身免疫特征的急性肝炎。
Imatinib mesylate-induced acute hepatitis with autoimmune features.
作者信息
Dhalluin-Venier Valérie, Besson Caroline, Dimet Stéphanie, Thirot-Bibault Anne, Tchernia Gilbert, Buffet Catherine
机构信息
Hepatogastroenterology, Bicêtre Hospital, LeKremlin Bicêtre, France.
出版信息
Eur J Gastroenterol Hepatol. 2006 Nov;18(11):1235-7. doi: 10.1097/01.meg.0000243867.56454.13.
Abstract
Autoimmune hepatitis is a disorder of unknown aetiology. Imatinib belongs to a new class of anticancer agents with high selectivity toward a specific molecular target. Its main indications are chronic myeloid leukaemia and gastrointestinal tumours. We report here, for the first time to our knowledge, imatinib mesylate-induced hepatitis with autoimmune features.
摘要
自身免疫性肝炎是一种病因不明的疾病。伊马替尼属于一类新型抗癌药物，对特定分子靶点具有高选择性。其主要适应证为慢性髓性白血病和胃肠道肿瘤。据我们所知，我们在此首次报告甲磺酸伊马替尼诱发的具有自身免疫特征的肝炎。
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