Maler J M, Spitzer P, Lewczuk P, Kornhuber J, Herrmann M, Wiltfang J
Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
Mol Psychiatry. 2006 Dec;11(12):1113-5. doi: 10.1038/sj.mp.4001913. Epub 2006 Oct 10.
Hematopoietic stem cells contribute to mammalian brain tissue regeneration by transdifferentiation processes. We found decreased counts of circulating CD34+ cells in early Alzheimer's dementia (AD; P = 0.01), which significantly correlated with age (r = -0.661; P = 0.001), cerebrospinal fluid beta-amyloid (Abeta)1-42 (r = -0.467; P = 0.025) and most pronounced the Abeta42/40 ratio (r = -0.688; P = 0.005). Our data suggest a deficient regenerative hematopoietic support for the central nervous system in early AD.
造血干细胞通过转分化过程促进哺乳动物脑组织再生。我们发现，早期阿尔茨海默病（AD）患者循环CD34+细胞计数减少（P = 0.01），这与年龄（r = -0.661；P = 0.001）、脑脊液β-淀粉样蛋白（Aβ）1-42（r = -0.467；P = 0.025）显著相关，与Aβ42/40比值的相关性最为显著（r = -0.688；P = 0.005）。我们的数据表明，早期AD患者中枢神经系统的造血再生支持不足。
