Callado L F, Garibi J M, Meana J J
Universidad del Pais Vasco, Facultad de Medicina y Odontologia, 48940 Leioa, Espana.
Rev Neurol. 2006;43(8):476-80.
To present the experimental data that support the hypothesis that the imidazoline I(2) receptors may be assessed as a biological marker to establish diagnosis and grade of human gliomas.
Gliomas constitute the most important group of brain neoplasm in humans. In these tumours accurate histopathologic diagnosis is a first crucial prerequisite for patient treatment. However, current grading schemes are still limited by subjective histologic criteria. Therefore, the search for new molecular and biological markers of gliomas represents a crucial step. In this context, it has been reported a significant increase in I(2) density in human gliomas when compared with normal brain tissue and other intracranial non-glial tumours. Moreover, this increase seems to fit well with the degree of malignancy in human gliomas. Thus, in glioblastomas multiformes the I(2) density is 1.4 times higher than in anaplastic astrocytomas and 2.2 higher than in low-grade astrocytomas.
The present results demonstrate that the measurement of the I(2) density by positron emission tomography techniques could be used in the future for grading and prognosis of human gliomas. This could avoid the current need for tumour biopsies in order to obtain a histopathologic diagnosis.
提供实验数据以支持以下假说，即咪唑啉I(2)受体可作为一种生物标志物用于人类胶质瘤的诊断和分级。
胶质瘤是人类最重要的脑肿瘤类型。在这些肿瘤中，准确的组织病理学诊断是患者治疗的首要关键前提。然而，目前的分级方案仍受主观组织学标准的限制。因此，寻找胶质瘤新的分子和生物标志物是关键的一步。在这种背景下，已有报道称与正常脑组织和其他颅内非胶质肿瘤相比，人类胶质瘤中I(2)密度显著增加。此外，这种增加似乎与人类胶质瘤的恶性程度高度吻合。因此，在多形性胶质母细胞瘤中，I(2)密度比间变性星形细胞瘤高1.4倍，比低级别星形细胞瘤高2.2倍。
目前的结果表明，未来正电子发射断层扫描技术测量I(2)密度可用于人类胶质瘤的分级和预后评估。这可以避免目前为获得组织病理学诊断而进行肿瘤活检的需求。
