Dumas Hervé, Panayiotopoulos Paris, Parker Dorothy, Pongpairochana Vincent
Serono International SA, 15 bis Chemin des Mines, Geneva, CH-1202, Switzerland.
BMC Endocr Disord. 2006 Oct 11;6:5. doi: 10.1186/1472-6823-6-5.
Recombinant human growth hormone (r-hGH) is used to treat: growth hormone deficiency in children and adults; children born small for gestational age; Turner's syndrome; and chronic renal failure. r-hGH is administered by daily subcutaneous injection and may be given using a number of different administration devices. The aim of this survey was, firstly, to identify which attributes of an r-hGH administration device are considered most important to physicians, teenage patients, parents of young children requiring GH and nurses who have experience of r-hGH administration, and, secondly, to determine how they rate existing devices in each of these key attributes.
The opinions of 67 individuals with experience in r-hGH administration were captured in discussion sessions. Parents, physicians and nurses were asked to rate 19 device attributes by completing a questionnaire, and to rank four different r-hGH administration devices (including a conceptual electronic device) in order of preference.
Reliability, ease of use, lack of pain during injection, safety in use, storage, and number of steps in preparation before use, during use and after were considered to be the five most desirable attributes of an r-hGH administration device. An electronic device was preferred to an automatic, multi-dose injection device, a needle-free injection device or a manual, ready-to-use, disposable injection device.
In the opinion of physicians, nurses and parents using r-hGH injection devices, an ideal device must combine reliability with simplicity, while delivering treatment with minimal pain. An electronic device, which combines many of the most useful features of existing devices with novel functions, was the preferred option for r-hGH administration.
重组人生长激素（r-hGH）用于治疗：儿童和成人的生长激素缺乏症；小于胎龄儿；特纳综合征；以及慢性肾衰竭。r-hGH通过每日皮下注射给药，可使用多种不同的给药装置。本次调查的目的，首先是确定r-hGH给药装置的哪些属性对医生、青少年患者、需要生长激素治疗的幼儿的父母以及有r-hGH给药经验的护士最为重要，其次是确定他们如何对现有装置在这些关键属性方面进行评分。
在讨论会上收集了67名有r-hGH给药经验的人员的意见。要求父母、医生和护士通过填写问卷对19种装置属性进行评分，并对四种不同的r-hGH给药装置（包括一种概念性电子装置）按偏好程度进行排序。
可靠性、易用性、注射时无疼痛、使用安全性、储存以及使用前、使用期间和使用后的准备步骤数量被认为是r-hGH给药装置最理想的五个属性。电子装置比自动多剂量注射装置、无针注射装置或手动即用型一次性注射装置更受青睐。
在使用r-hGH注射装置的医生、护士和父母看来，理想的装置必须将可靠性与简单性相结合，同时以最小的疼痛进行治疗。电子装置结合了现有装置的许多最有用的功能以及新颖的功能，是r-hGH给药的首选选项。
