Rabban Joseph T, Gupta Divya, Zaloudek Charles J, Chen Lee-May
Department of Pathology, University of California, San Francisco, CA 94143, USA.
Gynecol Oncol. 2006 Dec;103(3):1164-8. doi: 10.1016/j.ygyno.2006.09.005. Epub 2006 Oct 10.
Ovarian granulosa cell tumors are often associated with endometrial hyperplasia or carcinoma. The endometrial carcinoma is thought to occur under the influence of the estrogen receptor pathway and is typically a low-grade, low-stage endometrioid adenocarcinoma.
We present a case of a woman with a granulosa cell tumor of the ovary and a synchronous serous carcinoma of the endometrium. Immunohistochemical stains for estrogen receptors, progesterone receptors, and p53 protein were performed on both tumors.
Not all uterine tumors associated with ovarian granulosa cell tumors have low-risk histology. Preoperative evaluation of the uterus with attention to tumor subtyping is important for optimum staging and therapy.
卵巢颗粒细胞瘤常与子宫内膜增生或癌相关。子宫内膜癌被认为是在雌激素受体途径的影响下发生的，通常是低级别、低分期的子宫内膜样腺癌。
我们报告一例患有卵巢颗粒细胞瘤并同时患有子宫内膜浆液性癌的女性病例。对这两种肿瘤均进行了雌激素受体、孕激素受体和p53蛋白的免疫组化染色。
并非所有与卵巢颗粒细胞瘤相关的子宫肿瘤都具有低风险组织学特征。术前对子宫进行评估并关注肿瘤亚型对于最佳分期和治疗很重要。
