O'Mara Shane
Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland.
Behav Brain Res. 2006 Nov 11;174(2):304-12. doi: 10.1016/j.bbr.2006.08.018. Epub 2006 Oct 10.
The subiculum has a central position between the hippocampus proper and entorhinal and other cortices, as well as a range of subcortical structures. The functional role of subiculum within the hippocampal formation circuit remains largely unexplored and a theoretical and experimental consensus on its functions has yet to emerge. Presented here is a simple and speculative model of the functions of the subiculum, based partly on anatomical, behavioural and neurophysiological considerations. The model suggests, firstly, that the subiculum acts to amplify hippocampal output, given the prominent bursting behaviour of its neurons and, secondly, that there is a dorso-ventral segregation of function within the subiculum. The dorsal component appears principally concerned with the processing of information about space, movement and memory, whereas the ventral component appears to play a major regulatory role in the inhibition of the HPA axis.
海马下脚在海马体本身与内嗅皮质及其他皮质以及一系列皮质下结构之间处于中心位置。海马下脚在海马结构回路中的功能作用在很大程度上仍未得到探索，关于其功能的理论和实验共识尚未形成。本文提出了一个关于海马下脚功能的简单推测模型，该模型部分基于解剖学、行为学和神经生理学方面的考虑。该模型表明，首先，鉴于海马下脚神经元突出的爆发性行为，它起到放大海马输出的作用；其次，海马下脚内存在功能的背腹分离。背侧部分似乎主要与空间、运动和记忆信息的处理有关，而腹侧部分似乎在抑制下丘脑 - 垂体 - 肾上腺（HPA）轴方面发挥主要调节作用。
