Davis Margaret A, Hancock Dale D, Besser Thomas E, Daniels Joshua B, Baker Katherine N K, Call Douglas R
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA.
Vet Microbiol. 2007 Jan 31;119(2-4):221-30. doi: 10.1016/j.vetmic.2006.08.028. Epub 2006 Sep 1.
Salmonella enterica serovar Dublin (S. Dublin) is a cattle-adapted Salmonella serovar, so if antimicrobial resistance in S. Dublin arises as a result of antimicrobial use this most likely occurs within the cattle reservoir without impact from antimicrobial use in humans. We tested the antimicrobial resistance of bovine-origin S. Dublin isolates from 1986 through 2004 using a standard disk diffusion method. High proportions of isolates throughout the time period were resistant to one or more antimicrobials, and a marked increase in resistance to ceftazidime occurred between 2000 and 2004. Dairy-origin isolates were more likely to be resistant to several antibiotics than were isolates from beef operations where exposure to antimicrobials is likely to be less frequent. Plasmid analysis of a subset of isolates also supported the hypothesis that antimicrobial resistance traits in the cattle-adapted serovar Dublin were acquired within the bovine host environment.
肠炎沙门氏菌都柏林血清型（S. 都柏林）是一种适应牛的沙门氏菌血清型，因此，如果S. 都柏林的抗菌药物耐药性是由于使用抗菌药物而产生的，那么这种情况很可能发生在牛的宿主群体中，而不受人类使用抗菌药物的影响。我们使用标准纸片扩散法检测了1986年至2004年来自牛源的S. 都柏林分离株的抗菌药物耐药性。在整个时间段内，高比例的分离株对一种或多种抗菌药物耐药，并且在2000年至2004年间，对头孢他啶的耐药性显著增加。来自奶牛场的分离株比来自肉牛养殖场的分离株更有可能对几种抗生素耐药，因为肉牛养殖场接触抗菌药物的频率可能较低。对一部分分离株进行的质粒分析也支持了这样的假设，即适应牛的都柏林血清型中的抗菌药物耐药性特征是在牛宿主环境中获得的。
