Metallidis Simeon, Charokopos Nikolaos, Nikolaidis John, Alexiadou Efi, Lazaraki Georgia, Koumentaki Eleni, Tsona Afroditi, Theodoridis Georgios, Nikolaidis Pavlos
1st Internal Medicine Department, Infectious Diseases Division, AHEPA University Hospital, 1 Stilponos Kyriakidi Str., P.O. 54006, Thessaloniki, Greece.
Int J Antimicrob Agents. 2006 Nov;28(5):428-32. doi: 10.1016/j.ijantimicag.2006.08.019. Epub 2006 Oct 10.
This study investigated plasma and bone concentrations of moxifloxacin following a single intravenous dose of 400mg to consider its potential role in the treatment of osteomyelitis. Eight patients who underwent routine cardiopulmonary bypass surgery were enrolled in the study. Plasma and bone samples were collected 2h and 5h after the end of infusion. High performance liquid chromatography was used for the determination of moxifloxacin concentrations. Mean plasma concentrations were 3.36 microg/mL and 2.93 microg/mL at 2h and 5h after the end of infusion. The concentrations in the body and manubrium of the sternal bone were 1.65 microg/g and 1.64 microg/g at 2h and 1.4 microg/g and 1.45 microg/g at 5h, respectively. Moxifloxacin showed good penetration into bone and could be considered for the treatment of osteomyelitis.
本研究调查了单次静脉注射400mg莫西沙星后的血浆和骨浓度，以探讨其在骨髓炎治疗中的潜在作用。八名接受常规体外循环手术的患者参与了该研究。在输注结束后2小时和5小时采集血浆和骨样本。采用高效液相色谱法测定莫西沙星浓度。输注结束后2小时和5小时的平均血浆浓度分别为3.36μg/mL和2.93μg/mL。胸骨体和胸骨柄骨中的浓度在2小时分别为1.65μg/g和1.64μg/g，在5小时分别为1.4μg/g和1.45μg/g。莫西沙星在骨中显示出良好的渗透性，可考虑用于骨髓炎的治疗。
