采用“随机糖基化”策略合成双去氧糖基隐丹参酮皂苷及其抗肿瘤活性评价
Synthesis of bisdesmosidic kryptogenyl saponins using the 'random glycosylation' strategy and evaluation of their antitumor activity.
作者信息
Liu Yang, Zhao Dong-Mei, Lu Xue-Hua, Wang Hui, Chen Hong, Ke Ying, Leng Ling, Cheng Mao-Sheng
机构信息
Key Lab of New Drugs Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
出版信息
Bioorg Med Chem Lett. 2007 Jan 1;17(1):156-60. doi: 10.1016/j.bmcl.2006.09.071. Epub 2006 Oct 10.
PMID:17035008
Abstract
A bisdesmosidic steroidal saponins library, composed of 16 novel kryptogenin glycosides, was set up via six random glycosylation procedures, wherein two compounds showed their antitumor activity against HeLa cell in the preliminary pharmacological research.
摘要
通过六种随机糖基化方法构建了一个由16种新型海柯皂苷元糖苷组成的双糖苷甾体皂苷文库，其中两种化合物在初步药理研究中显示出对HeLa细胞的抗肿瘤活性。
相似文献
1
Synthesis of bisdesmosidic kryptogenyl saponins using the 'random glycosylation' strategy and evaluation of their antitumor activity.采用“随机糖基化”策略合成双去氧糖基隐丹参酮皂苷及其抗肿瘤活性评价
Bioorg Med Chem Lett. 2007 Jan 1;17(1):156-60. doi: 10.1016/j.bmcl.2006.09.071. Epub 2006 Oct 10.
2
Synthesis and antitumor activity of icogenin and its analogue.知母皂苷元及其类似物的合成与抗肿瘤活性
Bioorg Med Chem Lett. 2006 May 1;16(9):2454-8. doi: 10.1016/j.bmcl.2006.01.074. Epub 2006 Feb 15.
3
Synthesis and antitumor activity of 5,6-dihydro-17-hydroxy icogenin analogs.5,6-二氢-17-羟基剑麻皂素类似物的合成及抗肿瘤活性。
Eur J Med Chem. 2012 May;51:200-5. doi: 10.1016/j.ejmech.2012.02.043. Epub 2012 Mar 2.
4
Synthesis and antitumor activity of two natural N-acetylglucosamine-bearing triterpenoid saponins: lotoidoside D and E.两种天然含N-乙酰葡糖胺三萜皂苷：洛托苷D和E的合成及其抗肿瘤活性
Bioorg Med Chem Lett. 2006 Aug 15;16(16):4200-4. doi: 10.1016/j.bmcl.2006.05.086. Epub 2006 Jun 12.
5
Concise synthesis and antitumor activities of trisaccharide steroidal saponins.三糖甾体皂苷的简明合成及抗肿瘤活性。
Carbohydr Res. 2011 Nov 8;346(15):2406-13. doi: 10.1016/j.carres.2011.08.026. Epub 2011 Sep 1.
6
Synthesis and cytotoxic activity of two steroids: icogenin aglycone analogs.两种甾体化合物：异甘草素苷元类似物的合成及细胞毒性活性
J Asian Nat Prod Res. 2017 May;19(5):481-488. doi: 10.1080/10286020.2016.1228633. Epub 2016 Sep 22.
7
New insights into the structure-cytotoxicity relationship of spirostan saponins and related glycosides.甾体皂苷及其糖苷结构与细胞毒性关系的新认识。
Bioorg Med Chem. 2012 Apr 15;20(8):2690-700. doi: 10.1016/j.bmc.2012.02.026. Epub 2012 Feb 15.
8
Synthesis of novel spirostanic saponins and their cytotoxic activity.新型螺甾烷皂苷的合成及其细胞毒性活性。
Bioorg Med Chem. 2008 Feb 15;16(4):2063-76. doi: 10.1016/j.bmc.2007.10.089. Epub 2007 Nov 4.
9
Steroidal saponins from the whole plants of Agave utahensis and their cytotoxic activity.来自犹他龙舌兰全株的甾体皂苷及其细胞毒性活性。
Phytochemistry. 2009 Apr;70(6):807-15. doi: 10.1016/j.phytochem.2009.02.013. Epub 2009 Apr 22.
10
Efficient synthesis of trisaccharide saponins and their tumor cell killing effects through oncotic necrosis.通过胀亡作用高效合成三糖皂甙及其肿瘤细胞杀伤作用。
Bioorg Med Chem Lett. 2011 Jan 15;21(2):622-7. doi: 10.1016/j.bmcl.2010.12.046. Epub 2010 Dec 13.
Zotero 插件