Guan Yu-Yao, Li Shu-Zhen, Lei Ping-Sheng
a Pharmacy Department , Traffic Hospital of Shandong Province , Jinan 250031 , China.
b State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences , Beijing 100050 , China.
J Asian Nat Prod Res. 2017 May;19(5):481-488. doi: 10.1080/10286020.2016.1228633. Epub 2016 Sep 22.
During the process of icogenin analog research, we obtained two cytotoxic steroids: compound 4 and compound 6 casually. Their in vitro antitumor activities were tested by the standard MTT assay. The results disclosed that compound 4 (IC = 3.65-6.90 μM) showed potential antitumor activities against HELA, KB cell lines and compound 6 (IC = 2.40-9.05 μM) showed potential antitumor activities against HELA, BGC-823, KB, A549, HCT-8 cell lines.
在合成人参皂苷元类似物的研究过程中，我们偶然获得了两种具有细胞毒性的甾体化合物：化合物4和化合物6。采用标准MTT法检测了它们的体外抗肿瘤活性。结果表明，化合物4（IC50 = 3.65 - 6.90 μM）对HELA、KB细胞系显示出潜在的抗肿瘤活性，化合物6（IC50 = 2.40 - 9.05 μM）对HELA、BGC - 823、KB、A549、HCT - 8细胞系显示出潜在的抗肿瘤活性。
