Furlan Veronika, Bren Urban
Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia.
Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Glagoljaška 8, SI-6000 Koper, Slovenia.
Foods. 2023 Feb 13;12(4):802. doi: 10.3390/foods12040802.
(family Asteraceae), due to its various beneficial health effects, represents an important plant in the traditional medicine of Mediterranean countries. Currently, there is a renewed interest in this medicinal plant, especially in investigations involving the isolation and identification of its bioactive compounds from extracts and essential oils, as well as in experimental validation of their pharmacological activities. In this paper, we review the current knowledge on the beneficial health effects of extracts, essential oils, and their major bioactive polyphenolic compounds, ranging from antioxidative, anti-inflammatory, and anticarcinogenic activities to their antiviral, antimicrobial, insecticidal, and antiparasitic effects. This review also provides an overview of the most promising extraction and distillation techniques for obtaining high-quality extracts and essential oils from as well as methods for determining their antioxidative, antimicrobial, anti-inflammatory, and anticarcinogenic activities. Finally, new ideas for in silico studies of molecular mechanisms of bioactive polyphenols from , together with novel suggestions for their improved bioavailability through diverse encapsulation techniques, are introduced.
菊科植物因其多种有益健康的功效，在地中海国家的传统医学中是一种重要的植物。目前，人们对这种药用植物重新产生了兴趣，特别是在从提取物和精油中分离和鉴定其生物活性化合物的研究方面，以及在对其药理活性进行实验验证方面。在本文中，我们综述了目前关于提取物、精油及其主要生物活性多酚化合物有益健康功效的知识，范围涵盖抗氧化、抗炎、抗癌活性及其抗病毒、抗菌、杀虫和抗寄生虫作用。本综述还概述了从该植物中获得高质量提取物和精油最有前景的提取和蒸馏技术，以及测定其抗氧化、抗菌、抗炎和抗癌活性的方法。最后，介绍了对该植物生物活性多酚分子机制进行计算机模拟研究的新思路，以及通过多种包封技术提高其生物利用度的新建议。
