Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Biomed Res Int. 2017;2017:8968604. doi: 10.1155/2017/8968604. Epub 2017 Dec 4.
The present study is focused on the assessment of the medicinal therapeutic potential extracts of to investigate their pharmacological implications based upon science proofs. The antioxidant activity of fraction of , namely, -hexane (HR-1), ethyl acetate (HR-2), chloroform (HR-3), and -butanol (HR-4), was performed by using the DPPH radical scavenging method. The cytotoxicity and enzyme inhibition assessment were also performed. All the extracts showed significant antioxidant, antibacterial, and protein kinase inhibition but none of the extracts exhibited -amylase inhibition activity. The chloroform extract HR-3 may block a kinase receptor from binding to ATP; the lead molecule will be isolated, which may stop cancerous cell growth and demotion of cell division. It is predicted that ethyl acetate, chloroform, and -butanol extracts of contain polyphenolics, flavonoids, and alkaloids that are biologically effective candidates exhibiting significant cytotoxicity, antioxidant, and antimicrobial activities. They may control oxidative damage in the body tissues and act as potential antidiabetic and anticancer agents. These studies will also be helpful for future drug designing and drug development research.
本研究集中评估 的药用治疗潜力提取物，以根据科学证据研究其药理意义。采用 DPPH 自由基清除法测定 的正己烷（HR-1）、乙酸乙酯（HR-2）、氯仿（HR-3）和正丁醇（HR-4）馏分的抗氧化活性。还进行了细胞毒性和酶抑制评估。所有提取物均表现出显著的抗氧化、抗菌和蛋白激酶抑制作用，但没有一种提取物表现出对 -淀粉酶的抑制活性。氯仿提取物 HR-3 可能阻止激酶受体与 ATP 结合；将分离出先导分子，它可能阻止癌细胞生长和细胞分裂。预计 的乙酸乙酯、氯仿和正丁醇提取物含有多酚、类黄酮和生物碱，它们是具有生物活性的候选物，具有显著的细胞毒性、抗氧化和抗菌活性。它们可以控制体内组织的氧化损伤，并作为潜在的抗糖尿病和抗癌药物。这些研究也将有助于未来的药物设计和药物开发研究。
