Snoeck R, Andrei G, De Clercq E
Rega Institute for Medical Research, K.U. Leuven, B-3000 Leuven, Belgium.
Curr Opin Infect Dis. 1998 Dec;11(6):733-7. doi: 10.1097/00001432-199812000-00014.
Human papillomavirus induces the hyperproliferation of epithelial cells, leading to a broad spectrum of human diseases, ranging from benign warts to malignant neoplasms, depending on the location of the lesion, the immune status of the patient and the type of human papillomavirus. Current therapies for human papillomavirus-associated diseases are based on the excision or ablation of dysplastic or malignant tissue, and are associated with a high frequency of recurrent disease, discomfort and costs. A better understanding of the viral replicative cycle and of the interaction between the virus and the host cell, particularly the cell cycle regulation, has opened new perspectives. Recently, new treatment modalities for human papillomavirus-induced lesions have been identified, including the use of antiviral/immunomodulatory therapies, such as cidofovir, antisense oligonucleotides, imiquimod and human papillomavirus vaccines.
人乳头瘤病毒可诱导上皮细胞过度增殖，导致多种人类疾病，从良性疣到恶性肿瘤不等，这取决于病变部位、患者的免疫状态以及人乳头瘤病毒的类型。目前针对人乳头瘤病毒相关疾病的治疗方法是基于切除或消融发育异常或恶性组织，且疾病复发频率高、伴有不适且费用高昂。对病毒复制周期以及病毒与宿主细胞之间相互作用（尤其是细胞周期调控）的深入了解开辟了新的前景。最近，已确定了针对人乳头瘤病毒诱导病变的新治疗方式，包括使用抗病毒/免疫调节疗法，如西多福韦、反义寡核苷酸、咪喹莫特和人乳头瘤病毒疫苗。
