Boucher C A
Department of Clinical Virology, Utrecht University, Utrecht, The Netherlands.
Curr Opin Infect Dis. 1999 Feb;12(1):27-32. doi: 10.1097/00001432-199902000-00005.
The clinical indications for HIV drug resistance testing are discussed. The major limitations of using resistance testing in the clinical setting are the lack of evidence for a clinical benefit, the costs and the amount of knowledge required for a good interpretation of the results. In those situations in which these limitations can be overcome or are considered less important, resistance testing may be used today. For widespread clinical use, however, trials creating large databases and the design of expert systems translating the results for the use in individual patients will be required.
本文讨论了HIV耐药性检测的临床指征。在临床环境中使用耐药性检测的主要局限性在于缺乏临床获益的证据、成本以及准确解读结果所需的知识量。在这些局限性能够被克服或被认为不太重要的情况下，如今可以使用耐药性检测。然而，对于广泛的临床应用而言，还需要开展建立大型数据库的试验以及设计将结果转化以供个体患者使用的专家系统。
