Picozzi Giulia, Diciotti Stefano, Falchini Massimo, Foresti Silvia, Gallesi Francesca, Cavigli Edoardo, Livi Lorenzo, Villari Natale, Mascalchi Mario
Radiodiagnostic, Department of Clinical Physiopathology, University of Florence, Florence, Italy.
Invest Radiol. 2006 Nov;41(11):831-9. doi: 10.1097/01.rli.0000242837.11436.6e.
We sought to assess the reproducibility of size measurements of small lung nodules examined with low-dose thin-section computed tomography (LDTSCT).
Three radiologists measured volume with a semiautomatic tool and diameters manually of 20 (equivalent diameter range, 5.3-11 mm) phantom nodules and 37 (mean diameter range, 5-8.5 mm) lung nodules in subjects undergoing LDTSCT.
In phantoms, the worst 95% limits of agreement (95% LA) for volume were -3.0% and 3.0% within operator and -3.1% and 2.8% between operators. The coefficient of repeatability (CR) for diameter ranged between 0.51 and 0.67 mm within operator and the 95% LA were from -0.71 to 0.71 mm between operators. In nodules, the worst intraoperator 95% LA for volume were -14.4% and 17.6% within operator and -13.1% and 14.2% between operators. The CR for diameter ranged between 0.48 and 0.73 mm within operator and the 95% LA were from -1.16 to 1.16 mm between operators.
Operator-dependent variability of size measurements of small nodules examined with LDTSCT is not negligible and should be considered in lung cancer-screening studies.
我们试图评估低剂量薄层计算机断层扫描（LDTSCT）检查的小肺结节大小测量的可重复性。
三位放射科医生使用半自动工具测量20个（等效直径范围为5.3 - 11毫米）模拟结节以及37个（平均直径范围为5 - 8.5毫米）接受LDTSCT检查的受试者肺部结节的体积，并手动测量其直径。
在模拟结节中，体积测量的操作者内最差95%一致性界限（95%LA）为-3.0%和3.0%，操作者间为-3.1%和2.8%。直径的重复性系数（CR）在操作者内为0.51至0.67毫米，操作者间95%LA为-0.71至0.71毫米。在肺部结节中，体积测量的操作者内最差95%LA为-14.4%和17.6%，操作者间为-13.1%和14.2%。直径的CR在操作者内为0.48至0.73毫米，操作者间95%LA为-1.16至1.16毫米。
LDTSCT检查的小结节大小测量中，依赖操作者的变异性不可忽略，在肺癌筛查研究中应予以考虑。
