植物毒性内酯herbarumin III的短程对映选择性全合成。

A short enantioselective total synthesis of the phytotoxic lactone herbarumin III.

作者信息

Boruwa Joshodeep, Gogoi Naminita, Barua Nabin C

机构信息

Natural Products Chemistry Division, Regional Research Laboratory (CSIR), Jorhat, 785 006, Assam, India.

出版信息

Org Biomol Chem. 2006 Sep 21;4(18):3521-5. doi: 10.1039/b605982a. Epub 2006 Aug 14.

DOI:10.1039/b605982a

PMID:17036149

Abstract

The phytotoxic lactone herbarumin III has been synthesized in 11% overall yield. The approach applied uses Keck's asymmetric allylation and Sharpless epoxidation to build the key fragment. Esterification with 5-hexenoic acid and a ring closing metathesis was used to arrive at the target.

摘要

植物毒性内酯herbarumin III已被合成，总产率为11%。所采用的方法利用凯克不对称烯丙基化反应和夏普莱斯环氧化反应构建关键片段。通过与5-己烯酸进行酯化反应以及闭环复分解反应得到目标产物。