Marrink J, Sleijfer D T, de Vries E G, Schraffordt Koops H
Department of Internal Medicine, University Hospital, Groningen, The Netherlands.
Eur J Cancer. 1990;26(9):969-72. doi: 10.1016/0277-5379(90)90622-z.
To establish whether alpha-fetoprotein (AFP) produced in the early post-treatment phase of a patient with a germ cell tumour of the testis or the ovary originates from the tumour or is due to an underlying disturbance in liver function, the binding of AFP to concanavalin A (Con A) was investigated as a discriminative variable. A two-step assay is described that can distinguish the type of AFP produced at levels as low as 10 ng/ml. A Con A-binding ratio of 12-43% was found in the patients with disseminated germ cell tumours and in patients with AFP-positive gastrointestinal carcinomas. AFP from the liver gives ratios below 10%.
为确定睾丸或卵巢生殖细胞肿瘤患者治疗后早期产生的甲胎蛋白（AFP）是源于肿瘤还是由于潜在的肝功能紊乱，研究了AFP与伴刀豆球蛋白A（Con A）的结合情况作为鉴别变量。描述了一种两步检测法，该方法能够在低至10 ng/ml的水平区分所产生的AFP类型。在播散性生殖细胞肿瘤患者和AFP阳性的胃肠道癌患者中发现Con A结合率为12% - 43%。来自肝脏的AFP结合率低于10%。
