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不同恶性肿瘤患者血清甲胎蛋白的放射免疫测定

Radioimmunoassay of serum alpha-fetoprotein in patients with different maliganant tumors.

作者信息

Lie-Injo L E, Caldwell J, Ganesan S, Ganesan J

出版信息

Cancer. 1976 Jul;38(1):341-5. doi: 10.1002/1097-0142(197607)38:1<341::aid-cncr2820380150>3.0.co;2-g.

DOI:10.1002/1097-0142(197607)38:1<341::aid-cncr2820380150>3.0.co;2-g
PMID:59626
Abstract

The level of serum alpha-fetoprotein (AFP) was estimated by radioimmunoassay in 153 normal healthy Malysians of different ethnic groups. The mean level was 7.5 In1/ml (SD 2.28InU/ml). Among 330 patients with malignant tumors, 11 had increased levels of AFP. The only patient who had hepatoma had a very high level of serum AFP. High levels were also found in three of four patients with dysgerminoma of the ovary, in the only two patients with carcinoma of the testis, and in one patient with secondary carcinoma of the humerus of unknown origin. Lower, but significantly increased levels were observed in one patient (of 48) with breast carcinoma, one patient (of 8) with basal cell carcinoma of the nose, one patient (0f 27) with carcinoma of the lung, and one patient (of 59) with nasopharynegeal carcinoma.

摘要

采用放射免疫分析法对153名不同种族的马来西亚正常健康人血清甲胎蛋白(AFP)水平进行了测定。平均水平为7.5 In1/ml(标准差2.28InU/ml)。在330例恶性肿瘤患者中,11例AFP水平升高。唯一患肝癌的患者血清AFP水平极高。在4例卵巢无性细胞瘤患者中有3例、2例睾丸癌患者以及1例不明原发灶的肱骨继发性癌患者中也发现了高水平的AFP。在48例乳腺癌患者中的1例、8例鼻基底细胞癌患者中的1例、27例肺癌患者中的1例以及59例鼻咽癌患者中的1例中观察到较低但显著升高的水平。

相似文献

1
Radioimmunoassay of serum alpha-fetoprotein in patients with different maliganant tumors.不同恶性肿瘤患者血清甲胎蛋白的放射免疫测定
Cancer. 1976 Jul;38(1):341-5. doi: 10.1002/1097-0142(197607)38:1<341::aid-cncr2820380150>3.0.co;2-g.
2
Fetal proteins in various tumors.各种肿瘤中的胎儿蛋白。
Jpn J Exp Med. 1978 Aug;48(4):283-5.
3
Alpha-fetoprotein-lectin binding as a marker of tumour activity or liver damage.甲胎蛋白-凝集素结合作为肿瘤活性或肝损伤的标志物
Eur J Cancer. 1990;26(9):969-72. doi: 10.1016/0277-5379(90)90622-z.
4
Alpha-Fetoprotein levels in normal males from seven ethnic groups with different hepatocellular carcinoma risks.
Ann N Y Acad Sci. 1975 Aug 22;259:136-55. doi: 10.1111/j.1749-6632.1975.tb25410.x.
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Alpha-fetoprotein: occurrence in certain malignant diseases and review of clinical applications.
Med Clin North Am. 1970 May;54(3):797-803.
6
Alpha-1 antitrypsin (AAT) and alphafoetoprotein (AFP) in sera of patients with germ-cell neoplasms: value as tumour markers in patients with endodermal sinus tumour (yolk sac tumour).生殖细胞肿瘤患者血清中的α1抗胰蛋白酶(AAT)和甲胎蛋白(AFP):作为内胚窦瘤(卵黄囊瘤)患者肿瘤标志物的价值
Int J Cancer. 1977 Jun 15;19(6):741-6. doi: 10.1002/ijc.2910190602.
7
Alpha-fetoprotein and its relevance to human disease.甲胎蛋白及其与人类疾病的关联。
Gastroenterology. 1979 Oct;77(4 Pt 1):787-96.
8
[Serum alpha-fetoproteins and cancer of the liver].[血清甲胎蛋白与肝癌]
Acta Gastroenterol Latinoam. 1972 Jul-Sep;4(3):117-8.
9
Alpha-fetoprotein. Occurrence in germinal cell and liver malignancies.甲胎蛋白。在生殖细胞和肝脏恶性肿瘤中的出现情况。
Am J Med. 1971 Dec;51(6):767-71. doi: 10.1016/0002-9343(71)90304-4.
10
Affinity chromatography used in distinguishing alpha-fetoprotein in serum from patients with tumors of hepatic parenchyma and of germ cells.亲和层析法用于区分肝实质肿瘤和生殖细胞肿瘤患者血清中的甲胎蛋白。
Clin Chem. 1984 Jul;30(7):1257-8.

引用本文的文献

1
Alpha-fetoprotein, alpha-1-antitrypsin, and transferrin in gonadal yolk-sac tumours.性腺卵黄囊瘤中的甲胎蛋白、α1抗胰蛋白酶和转铁蛋白
J Clin Pathol. 1979 May;32(5):455-61. doi: 10.1136/jcp.32.5.455.