Niedbala W, Cai B, Liew F Y
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, UK.
Ann Rheum Dis. 2006 Nov;65 Suppl 3(Suppl 3):iii37-40. doi: 10.1136/ard.2006.058446.
There is a close relation between T helper (Th) 1 cells and nitric oxide in disease. Thus it is possible that a reciprocal regulatory mechanism exists between them. This paper briefly describes the experimental studies which have helped elucidate the mechanism by which nitric oxide selectively enhances Th 1 cell proliferation and the potential effect of nitric oxide on regulatory T (Treg) cells. On the basis of the results the authors propose that nitric oxide represents an additional signal for the induction of T cell subset response, contributing to the increasingly complex network of immune regulation essential for health and disease.
在疾病中，辅助性T（Th）1细胞与一氧化氮之间存在密切关系。因此，它们之间可能存在一种相互调节机制。本文简要描述了一些实验研究，这些研究有助于阐明一氧化氮选择性增强Th1细胞增殖的机制以及一氧化氮对调节性T（Treg）细胞的潜在影响。基于这些结果，作者提出一氧化氮代表诱导T细胞亚群反应的另一种信号，有助于构成对健康和疾病至关重要的日益复杂的免疫调节网络。
