Zeigler Brandon M, Sugiyama Daisuke, Chen Michael, Guo Yalin, Downs Karen M, Speck Nancy A
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.
Development. 2006 Nov;133(21):4183-92. doi: 10.1242/dev.02596.
The chorio-allantoic placenta forms through the fusion of the allantois (progenitor tissue of the umbilical cord), with the chorionic plate. The murine placenta contains high levels of hematopoietic stem cells, and is therefore a stem cell niche. However, it is not known whether the placenta is a site of hematopoietic cell emergence, or whether hematopoietic cells originate from other sites in the conceptus and then colonize the placenta. Here, we show that the allantois and chorion, isolated prior to the establishment of circulation, have the potential to give rise to myeloid and definitive erythroid cells following explant culture. We further show that the hematopoietic potential of the allantois and chorion does not require their union, indicating that it is an intrinsic property of these tissues. These results suggest that the placenta is not only a niche for, but also a source of, hematopoietic cells.
绒毛膜尿囊胎盘是通过尿囊（脐带的祖组织）与绒毛膜板融合形成的。鼠胎盘含有高水平的造血干细胞，因此是一个干细胞龛。然而，尚不清楚胎盘是否是造血细胞出现的部位，或者造血细胞是否起源于胚胎中的其他部位，然后定植于胎盘。在这里，我们表明，在循环建立之前分离的尿囊和绒毛膜，在外植体培养后有产生髓系细胞和定型红细胞的潜力。我们进一步表明，尿囊和绒毛膜的造血潜力并不需要它们的结合，这表明这是这些组织的固有特性。这些结果表明，胎盘不仅是造血细胞的龛，也是造血细胞的来源。
