Kühnl P, Sibrowski W, Böhm B O, Bender S W, Kalmar G, Löliger C
Dept. Transfusion Medicine and Transplantation Immunology Univ. Hamburg, FRG.
Beitr Infusionsther. 1990;26:283-6.
A possible association of Crohn's disease (CD) with MHC (major histocompatibility complex) markers was investigated in families with more than one affected member. HLA-A, B, C, DR and DQ typing was performed in 21 CD families with two or more CD patients. The following HLA-antigens showed increased relative risk (RR) values for CD: B44 (RR = 2.43; B15 (Bw62, Bw63) (RR = 2.03); DR7 (RR = 1.85); DR4 (RR = 1.06). Three of 44 patients were DR4- and four DR7-homozygous. The risk haplotype B44/DR7 was observed in four and Bw62/DR4 in three CD patients, respectively. CD affected family members (female greater than male) shared HLA haplotypes more frequently than expected by mendelian laws. None of the differences reached statistical significance.
在有不止一名患病成员的家庭中，研究了克罗恩病（CD）与主要组织相容性复合体（MHC）标记之间可能存在的关联。对21个有两名或更多CD患者的家庭进行了HLA - A、B、C、DR和DQ分型。以下HLA抗原显示出CD的相对风险（RR）值增加：B44（RR = 2.43）；B15（Bw62、Bw63）（RR = 2.03）；DR7（RR = 1.85）；DR4（RR = 1.06）。44名患者中有3名是DR4纯合子，4名是DR7纯合子。分别在4名和3名CD患者中观察到风险单倍型B44/DR7和Bw62/DR4。受CD影响的家庭成员（女性多于男性）共享HLA单倍型的频率高于孟德尔定律预期。这些差异均未达到统计学意义。
