Smolen J S, Gangl A, Polterauer P, Menzel E J, Mayr W R
Gastroenterology. 1982 Jan;82(1):34-8.
HLA-A, B, C, and DR antigens were studied in 27 Viennese patients with Crohn's disease and 30 patients with ulcerative colitis. The frequency of HLA-B12 was found to be significantly (p less than 0.001, pc less than 0.05) increased in patients with Crohn's disease (52%) as compared with both healthy controls (21%) and patients with ulcerative colitis (10%). The frequency of HLA-Cw5 was slightly increased in Crohn's disease; however, the corrected p value was not significant. With regard to HLA-DR antigens, differences between the study groups and the controls or between ulcerative colitis and Crohn's disease did not reach statistical significance. However, the concomitant occurrence of HLA-B12 and/or Cw5 and/or DR7 was observed in 11 Crohn's disease and no ulcerative colitis patient (pc less than 0.006); there is a known linkage disequilibrium between these antigens. Although they differ from previous reports, these data in conjunction with the recently disclosed increased HLA recombination frequency in patients with Crohn's disease indicate that genes coding for HLA antigens may play a role in the pathogenesis of Crohn's disease.
对27例维也纳克罗恩病患者和30例溃疡性结肠炎患者的HLA - A、B、C和DR抗原进行了研究。发现与健康对照者（21%）和溃疡性结肠炎患者（10%）相比，克罗恩病患者中HLA - B12的频率显著升高（p小于0.001，校正p小于0.05）（52%）。克罗恩病患者中HLA - Cw5的频率略有升高；然而，校正后的p值不显著。关于HLA - DR抗原，研究组与对照组之间或溃疡性结肠炎与克罗恩病之间的差异未达到统计学意义。然而，在11例克罗恩病患者中观察到HLA - B12和/或Cw5和/或DR7同时出现，而溃疡性结肠炎患者中未观察到（校正p小于0.006）；这些抗原之间存在已知的连锁不平衡。尽管这些数据与先前的报告不同，但这些数据与最近披露的克罗恩病患者中HLA重组频率增加相结合，表明编码HLA抗原的基因可能在克罗恩病的发病机制中起作用。
