Morais Cristiane G, Soares Irene S, Carvalho Luzia H, Fontes Cor J F, Krettli Antoniana U, Braga Erika M
Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Am J Trop Med Hyg. 2006 Oct;75(4):582-7.
The antibody responses to the apical membrane antigen 1 of the Plasmodium vivax (PvAMA-1) were investigated in subjects living in areas of Brazil with different levels of malaria transmission. The prevalence and the levels of IgG to PvAMA-1 increased with the time of exposure. The frequency of a positive response and the mean IgG level were higher in areas where malaria prevalence was more intense, especially among non-infected subjects exposed to moderate transmission over a period of 20 years. The proportions and levels of IgG1and IgG3 isotypes were significantly higher among those subjects with long-term exposure. Antibodies, mainly IgG1, to PvAMA-1 persisted for seven years among subjects briefly exposed to malaria in an outbreak outside the Brazilian malaria-endemic area. These data show the highly immunogenic properties of PvAMA-1 and emphasize its possible use as a malaria vaccine candidate.
在巴西疟疾传播水平不同地区生活的人群中，对间日疟原虫顶端膜抗原1（PvAMA-1）的抗体反应进行了调查。针对PvAMA-1的IgG流行率和水平随暴露时间增加。在疟疾流行更严重的地区，阳性反应频率和平均IgG水平更高，尤其是在20年期间暴露于中度传播的未感染人群中。长期暴露人群中IgG1和IgG3同种型的比例和水平显著更高。在巴西疟疾流行区以外一次疫情中短暂接触疟疾的人群中，针对PvAMA-1的抗体（主要是IgG1）持续了七年。这些数据显示了PvAMA-1具有高度免疫原性，并强调了其作为疟疾疫苗候选物的潜在用途。
