Paddock Christopher D, Koss Tamara, Eremeeva Marina E, Dasch Gregory A, Zaki Sherif R, Sumner John W
Viral and Rickettsial Zoonoses Branch and Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Am J Trop Med Hyg. 2006 Oct;75(4):732-8.
Rickettsialpox is a cosmopolitan, mite-borne, spotted fever rickettsiosis caused by Rickettsia akari. The disease is characterized by a primary eschar, fever, and a papulovesicular rash. Rickettsialpox was first identified in New York City in 1946 and the preponderance of recognized cases in the United States continues to originate from this large metropolitan center. The most recently isolated U.S. strain of R. akari was obtained more than a half century ago. We describe the culture and initial characterization of five contemporaneous isolates of R. akari obtained from eschar biopsy specimens from New York City patients with rickettsialpox. This work emphasizes the importance and utility of culture-and molecular-based methods for the diagnosis of rickettsialpox and other eschar-associated illnesses.
立克次体痘是一种由小蛛立克次体引起的世界性、螨传播的斑点热立克次体病。该病的特征为原发性焦痂、发热和丘疹水疱性皮疹。立克次体痘于1946年在纽约市首次被发现，在美国，大多数已确诊病例仍源自这个大型都市中心。最近一次分离出的美国小蛛立克次体菌株是在半个多世纪以前获得的。我们描述了从纽约市立克次体痘患者的焦痂活检标本中获得的5株同期小蛛立克次体分离株的培养及初步鉴定。这项工作强调了基于培养和分子方法在诊断立克次体痘及其他与焦痂相关疾病中的重要性和实用性。
