Lakshmanan Nallakannu, Gore Thomas C, Duncan Karen L, Coyne Michael J, Lum Melissa A, Sterner Frank J
Intervet Inc., 29160 Intervet Lane, Millsboro, DE 19966, USA.
Vet Ther. 2006 Fall;7(3):223-31.
Thirty-two seronegative pups were vaccinated at 8 weeks of age with modified-live canine distemper virus (CDV), canine adenovirus type-2 (CAV-2), and canine parvovirus (CPV) vaccine and at 12 weeks with a modified-live CDV, CAV-2, CPV, and killed rabies virus vaccine. An additional 31 seronegative pups served as age-matched, nonvaccinated controls. All test dogs were strictly isolated for 3 years after receiving the second vaccination and then were challenged with virulent rabies virus. Clinical signs of rabies were prevented in 28 (88%) of the 32 vaccinated dogs. In contrast, 97% (30 of 31) of the control dogs died of rabies infection. These study results indicated that no immunogenic interference occurred between the modified-live vaccine components and the killed rabies virus component. Furthermore, these results indicated that the rabies component in the test vaccine provided protection against virulent rabies challenge in dogs 12 weeks of age or older for a minimum of 3 years following vaccination.
32只血清阴性幼犬在8周龄时接种了犬瘟热病毒（CDV）、犬腺病毒2型（CAV-2）和犬细小病毒（CPV）的改良活疫苗，在12周龄时接种了CDV、CAV-2、CPV的改良活疫苗以及狂犬病病毒灭活疫苗。另外31只血清阴性幼犬作为年龄匹配的未接种疫苗的对照。所有受试犬在接受第二次疫苗接种后严格隔离3年，然后用强毒狂犬病病毒进行攻击。32只接种疫苗的犬中有28只（88%）预防了狂犬病的临床症状。相比之下，97%（31只中的30只）的对照犬死于狂犬病感染。这些研究结果表明，改良活疫苗成分与狂犬病病毒灭活成分之间未发生免疫原性干扰。此外，这些结果表明，受试疫苗中的狂犬病成分在接种疫苗后至少3年内为12周龄及以上的犬提供了针对强毒狂犬病攻击的保护。
