Ficken Martin D, Ellsworth Michael A, Tucker Cassius M
Benchmark BioLabs, Inc., 421 West Industrial Lake Drive, Lincoln, Nebraska 68528, USA.
Vet Ther. 2006 Fall;7(3):283-94.
This study demonstrated that the modified-live bovine viral diarrhea virus (BVDV) type 1 and 2 fractions of a multivalent vaccine protected pregnant heifers and their fetuses against virulent BVDV types 1 and 2 challenge exposures at 370 days after vaccination. All BVDV vaccinated heifers inoculated with either BVDV type 1 or 2 at approximately 62 to 94 days of gestation delivered fetuses or calves that were negative for BVDV by ear-notch immunohistochemistry and virus isolation and serum neutralization on a prenursing serum sample. In comparison, eight of nine and 10 of 10 fetuses or calves from non-BVDV-vaccinated heifers were considered persistently infected following exposure to BVDV type 1 and type 2, respectively.
本研究表明，一种多价疫苗中经改良的1型和2型牛病毒性腹泻病毒（BVDV）组分，可在接种疫苗370天后保护怀孕的小母牛及其胎儿免受1型和2型强毒BVDV攻击。所有在妊娠约62至94天时接种1型或2型BVDV的接种了BVDV疫苗的小母牛，产出的胎儿或小牛通过耳缺刻免疫组化、病毒分离以及对哺乳前血清样本进行血清中和试验，结果显示BVDV呈阴性。相比之下，未接种BVDV疫苗的小母牛所产的9头胎儿或小牛中有8头，以及10头胎儿或小牛中有10头，在分别接触1型和2型BVDV后被认为发生了持续性感染。
