Walz Paul H, Chamorro Manuel F, M Falkenberg Shollie, Passler Thomas, van der Meer Frank, R Woolums Amelia
College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.
USDA Agricultural Research Service, National Animal Disease Center, Ames, Iowa, USA.
J Vet Intern Med. 2020 Sep;34(5):1690-1706. doi: 10.1111/jvim.15816. Epub 2020 Jul 7.
Control of bovine viral diarrhea virus (BVDV) in cattle populations across most of the world has remained elusive in spite of advances in knowledge about this viral pathogen. A central feature of virus perseverance in cattle herds is the unique mechanism of persistent infection. Managing BVDV infection in herds involves controlling persistently infected carrier animals using a multidimensional approach of vaccination, biosecurity, and identification of BVDV reservoirs. A decade has passed since the original American College of Veterinary Internal Medicine consensus statement on BVDV. While much has remained the same with respect to clinical signs of disease, pathogenesis of infection including persistent infection, and diagnosis, scientific articles published since 2010 have led to a greater understanding of difficulties associated with control of BVDV. This consensus statement update on BVDV presents greater focus on topics currently relevant to the biology and control of this viral pathogen of cattle, including changes in virus subpopulations, infection in heterologous hosts, immunosuppression, and vaccination.
尽管在对这种病毒病原体的认识上取得了进展，但在世界上大多数地区的牛群中，控制牛病毒性腹泻病毒（BVDV）仍然难以实现。病毒在牛群中持续存在的一个核心特征是持续感染的独特机制。在牛群中管理BVDV感染涉及使用疫苗接种、生物安全和识别BVDV储存库的多维方法来控制持续感染的携带动物。自美国兽医内科学院关于BVDV的最初共识声明发布以来，已经过去了十年。虽然疾病的临床症状、包括持续感染在内的感染发病机制以及诊断方面许多情况仍然相同，但自2010年以来发表的科学文章使人们对与控制BVDV相关的困难有了更深入的了解。这份关于BVDV的共识声明更新更加关注当前与这种牛病毒病原体的生物学和控制相关的主题，包括病毒亚群的变化、异源宿主中的感染、免疫抑制和疫苗接种。
