Serfling Edgar, Klein-Hessling Stefan, Palmetshofer Alois, Bopp Tobias, Stassen Michael, Schmitt Edgar
Department of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.
Eur J Immunol. 2006 Nov;36(11):2837-43. doi: 10.1002/eji.200536618.
The Ca++-regulated calcineurin/NFAT cascade is one of the crucial signalling pathways that controls adaptive immunity. However, a number of novel experimental data suggest that, in addition to their role in T cell activation, NFATc transcription factors play also a decisive role in the generation of peripheral tolerance against self-antigens. This function of NFATc factors is mediated by controlling activation-induced cell death and clonal anergy of T helper cells and the activity of regulatory T cells. The multi-functional role of NFATc proteins characterize these transcription factors as key regulators of immunological tolerance and, if dysregulated, of development of autoimmune diseases.
钙离子调节的钙调神经磷酸酶/活化T细胞核因子（Ca++-regulated calcineurin/NFAT）级联反应是控制适应性免疫的关键信号通路之一。然而，大量新的实验数据表明，除了在T细胞活化中发挥作用外，NFATc转录因子在对外源自身抗原产生外周耐受方面也起着决定性作用。NFATc因子的这一功能是通过控制辅助性T细胞的活化诱导细胞死亡和克隆无能以及调节性T细胞的活性来介导的。NFATc蛋白的多功能作用将这些转录因子表征为免疫耐受的关键调节因子，若其失调，则会导致自身免疫性疾病的发生。
