Herrero T, Tornero P, Infante S, Fuentes V, Sánchez M N, De Barrio M, Baeza M L
Allergy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
J Investig Allergol Clin Immunol. 2006;16(5):327-30.
Hypersensitivity reactions to oxaliplatin have been increasing since its introduction at the end of the 1990s, but allergy tests with antineoplastic drugs are rarely used to aid diagnosis. We describe 5 cases in which hypersensitivity reactions to oxaliplatin after several courses of chemotherapy were managed by allergy testing and desensitization. Skin prick tests were negative at 1 mg/mL in all patients, positive at 10 mg/mL in 2 tested patients, and negative in 10 control subjects. Intradermal tests were positive and not irritant at 0.01 to 0.001 mg/mL concentrations. A desensitization protocol with increasing concentrations and flow rates was successfully completed in all patients. We conclude that prick and intradermal skin tests are useful in the diagnosis of hypersensitivity reactions to oxaliplatin and that the desensitization protocol performed avoided discontinuation of chemotherapy in all patients.
自20世纪90年代末奥沙利铂问世以来，对其过敏反应不断增加，但很少使用抗肿瘤药物过敏试验来辅助诊断。我们描述了5例在接受几个疗程化疗后出现奥沙利铂过敏反应的病例，通过过敏试验和脱敏治疗进行处理。所有患者皮内试验在1mg/mL时均为阴性，2例受试患者在10mg/mL时为阳性，10例对照受试者为阴性。皮内试验在浓度为0.01至0.001mg/mL时为阳性且无刺激性。所有患者均成功完成了浓度和流速递增的脱敏方案。我们得出结论，点刺试验和皮内试验有助于诊断奥沙利铂过敏反应，所进行的脱敏方案避免了所有患者化疗的中断。
