Zhang Hong-quan, Ge Hui, Cheng Mei-ying
The Medical and Pharmaceutical Academy, Yangzhou University, Yangzhou 225001, China.
Yao Xue Xue Bao. 2006 Aug;41(8):797-800.
To study the inhibitory effect and mechanism of nobiletin on Heps tumor bearing mice.
Models of Heps tumor bearing mice were established. The inhibitory rates of tumor growth were calculated, the apoptosis morphology of tumor tissue was observed. The T lymphocyte transformation capacity was tested by MTT assay, the TNFalpha and IL-2 production were measured by LDH kits.
Nobiletin could significantly inhibit Heps tumor growth. The inhibitory rates were 42.14% - 65.09% (P < 0.01). The morphology of tumor tissues in nobiletin group had typical characters of necrosis and apoptosis through transmission electron microscope. Nobiletin could stimulate T lymphocyte transformation and the production of TNFalpha and IL-2.
Nobiletin has obvious antitumor effect on Heps, the main mechanism is to enhance the cellular immune function and induce apoptosis of tumor tissue.
研究橙皮素对荷Heps瘤小鼠的抑制作用及其机制。
建立荷Heps瘤小鼠模型。计算肿瘤生长抑制率，观察肿瘤组织的凋亡形态。采用MTT法检测T淋巴细胞转化能力，用LDH试剂盒检测TNFα和IL-2的产生。
橙皮素能显著抑制Heps肿瘤生长。抑制率为42.14% - 65.09%（P < 0.01）。通过透射电镜观察，橙皮素组肿瘤组织形态具有典型的坏死和凋亡特征。橙皮素能刺激T淋巴细胞转化以及TNFα和IL-2的产生。
橙皮素对Heps具有明显的抗肿瘤作用，其主要机制是增强细胞免疫功能并诱导肿瘤组织凋亡。
