Sun Xiukun, Xu Aie, Wei Xiaodong, Ouyang Jie, Lu Liangjun, Chen Meihua, Zhang Dimin
Department of Dermatology, Third People's Hospital of Hangzhou, Hangzhou, China.
Int J Dermatol. 2006 Oct;45(10):1176-81. doi: 10.1111/j.1365-4632.2006.02907.x.
Genetic factors are thought to be involved in the development of vitiligo.
To explore the possible genetic model of vitiligo by analyzing the genetic characteristics of 815 patients and their families from south China (Zhejiang Province).
Data for 815 patients with vitiligo were obtained by questionnaire. The inheritance pattern estimation, heritability calculation, and complex segregation analysis were performed using the Penrose method, Falconer regression method, and SAGE-REGTL program, respectively.
In 815 vitiligo probands, 128 (15.7%) had a family history. The ratio of the sibling prevalence rate to the population prevalence rate (s/q) approached 1/square root q using the Penrose calculation, and the heritability degrees of vitiligo in the first- and second-degree relatives were 59.6% and 55.2%, respectively. The complex segregation analysis suggested that the dominant model was the best-fit genetic model for vitiligo.
Genetic factors play an important role in the occurrence of vitiligo, and the genetic model of vitiligo in this population is consistent with a polygenetic or multifactorial inheritance in a dominant major gene pattern.
遗传因素被认为与白癜风的发病有关。
通过分析来自中国南方（浙江省）的815例患者及其家族的遗传特征，探讨白癜风可能的遗传模式。
通过问卷调查获取815例白癜风患者的数据。分别采用彭罗斯法、法尔科纳回归法和SAGE-REGTL程序进行遗传模式估计、遗传度计算和复杂分离分析。
在815例白癜风先证者中，128例（15.7%）有家族史。采用彭罗斯计算法，同胞患病率与人群患病率之比（s/q）接近1/√q，白癜风在一级和二级亲属中的遗传度分别为59.6%和55.2%。复杂分离分析表明，显性模型是最适合白癜风的遗传模型。
遗传因素在白癜风的发病中起重要作用，该人群中白癜风的遗传模式符合多基因或多因素遗传的显性主基因模式。
