[寻常型银屑病遗传模式分析]
[Analyses of genetic model of psoriasis vulgaris].
作者信息
Zhang Xuejun, Wang Hongyan, Chen Shanyu, Wang Fuxi, Liu Taofeng, Wang Zaixing, Li Ming, Yang Sen
机构信息
Institute of Dermatology and Department of Dermatology, Anhui Medical University, Hefei, Anhui, 230022 P. R. China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Apr;19(2):108-11.
OBJECTIVE
To explore the possible genetic model of psoriasis vulgaris.
METHODS
The complex segregation analysis and heritability calculation were performed with the aid of Penrose method, Falconer regression method and SAGE-REGTL program.
RESULTS
It was found that in 1043 patients with psoriasis vulgaris, 305 patients (29.24%) have the family history of psoriasis, and 738 patients have not the family history. A ratio of s/q approached 1/(square root of q) with Penrose method, and the heritability values of psoriasis in the first-degree and second-degree relatives were 67.04%, 46.6% respectively. By complex segregation analysis, Mendelian, non-major-gene model and environment model were rejected for psoriasis.
CONCLUSION
The results suggest that psoriasis follows a pattern of polygenetic or multifactorial inheritance rather than single-gene inheritance.
目的
探讨寻常型银屑病可能的遗传模式。
方法
借助彭罗斯法、法尔科纳回归法和SAGE - REGTL程序进行复杂分离分析和遗传度计算。
结果
发现1043例寻常型银屑病患者中，305例（29.24%）有银屑病家族史，738例无家族史。采用彭罗斯法时，s/q比值接近1/（q的平方根），银屑病在一级亲属和二级亲属中的遗传度值分别为67.04%、46.6%。通过复杂分离分析，银屑病的孟德尔遗传模式、非主基因模型和环境模型均被排除。
结论
结果表明，银屑病遵循多基因或多因素遗传模式，而非单基因遗传。
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