Chung Jin Woong, Jeon Jun-Ho, Yoon Suk-Ran, Choi Inpyo
Laboratory of Immunology, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon 305-333, Republic of Korea.
J Dermatol. 2006 Oct;33(10):662-9. doi: 10.1111/j.1346-8138.2006.00156.x.
Vitamin D(3) upregulated protein 1 (VDUP1) is a 46-kDa multifunctional protein, initially isolated in HL-60 cells as a protein of which expression is upregulated by vitamin D(3) administration. Subsequently, it was identified independently by investigators from diverse scientific backgrounds as a thioredoxin binding protein that negatively regulates the expression and the activity of thioredoxin, and is thus involved in redox regulation. Further studies have revealed that VDUP1 plays multiple roles in a wide range of cellular processes such as proliferation or apoptosis. Recently, it has been reported that VDUP1 is also involved in the immune system via positive regulation of natural killer development. In addition, VDUP1 has been revealed to be associated with the fatty acid utilization. In the present review, we discuss the novel aspects of VDUP1 function as well as the historical background of VDUP1. Future studies will explore the diagnostic and therapeutic potential of modulating the function of VDUP1 in vivo.
维生素D(3)上调蛋白1（VDUP1）是一种46 kDa的多功能蛋白，最初在HL-60细胞中作为一种其表达可通过给予维生素D(3)而上调的蛋白被分离出来。随后，来自不同科学背景的研究人员独立地将其鉴定为一种硫氧还蛋白结合蛋白，该蛋白对硫氧还蛋白的表达和活性起负调节作用，因此参与氧化还原调节。进一步的研究表明，VDUP1在广泛的细胞过程如增殖或凋亡中发挥多种作用。最近，有报道称VDUP1还通过对自然杀伤细胞发育的正向调节参与免疫系统。此外，已揭示VDUP1与脂肪酸利用有关。在本综述中，我们讨论了VDUP1功能的新方面以及VDUP1的历史背景。未来的研究将探索在体内调节VDUP1功能的诊断和治疗潜力。
